Plectin protein

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August undefined, 2024

Webb5 aug. 2024 · The human plectin gene (PLEC) on chromosome 8q24 codes for a 4,684 amino acids large protein whose isoforms [] are key for the functional and structural organization of filamentous cytoskeletal networks, thereby contributing to fundamental biomechanical properties of mechanical stress-bearing tissues [].Plectinopathies thus … WebbThe cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant hallmarks in many human cancers due to its involvement in various cellular activities contributing to ...

NCBI Conserved Domain Search

WebbPlectin has recently been identified as a widespread and abundant cytoplasmic protein of mammalian cells. In this article the available data on plectin are reviewed, focusing on … Webb13 maj 2015 · The faster migration of rodless plectin keratinocytes is not due to altered biochemical properties because, like full-length plectin, rodless plectin is a dimeric protein. Our data demonstrate that rodless plectin can functionally compensate for the loss of full-length plectin in mice. unleash experience management

NM_201384.3(PLEC):c.8495G>A (p.Arg2832His) AND not specified

Webb15 aug. 2015 · Plectin, a versatile 500-kDa cytolinker protein, is essential for muscle fiber integrity and function. The most common disease caused by mutations in the human … WebbPlectin was expressed in all adult and fetal tissues examined except leukocytes. Only a weak band was obtained from adult brain and thymus. Natsuga et al. (2010) determined that human fibroblasts express 2 different plectin isoforms: a 500-kD full-length protein and a 390-kD protein lacking the rod domain. WebbTo confirm the absence of plectin expression in mutant mice on the protein level, skin and muscle tissue homogenates prepared from mutant and wild-type mice were analyzed by immunoblotting using a rabbit anti-plectin antiserum (Figs. 1D and 2D) and monoclonal antibodies to plectin (data not shown), both immunoreactive with the rod domain of the … unleashes crossword clue

Plectin: a cytolinker by design - PubMed

PLEC Gene - Altmeyers Encyclopedia - Department Dermatology

Webb21 dec. 2024 · Plectin, as a cytoskeleton-related protein, is involved in various physiological and pathological processes of many cell types. Studies have found that plectin affects cancer cell invasion and metastasis, but the exact mechanism is not fully understood. In this study, we aim to investigate the role of plectin in the migration of … Webb21 apr. 2024 · As such, therapeutic targeting of plectin, its protein interactors, and in particular, cancer-specific plectin (CSP), presents an attractive opportunity to impede carcinogenesis directly”. The article reports on plectin’s differential gene and protein expression in cancer, explores its mutational profile, and discusses the current … recess king electricWebbPlectin is a cytoskeletal linker protein which has a long central rod and N- and C-terminal globular domains. Mutations in the gene encoding plectin (PLEC) cause two distinct … recessive lethal genes in livestock

"Webb5 mars 2024 · Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability through the integration of intermediate filaments (IFs) with cell … " - Plectin protein

Plectin protein

CDD Conserved Protein Domain Family: S10_plectin

WebbPlectin is a cytoskeletal protein of >500 kDa that forms dumbbell-shaped homodimers comprising a central parallel alpha-helical coiled coil rod domain flanked by globular … Webb30 apr. 1996 · Plectin, a 500-kDa intermediate filament binding protein, has been proposed to provide mechanical strength to cells and tissues by acting as a cross-linking element …

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Webb14 okt. 2008 · Protein names Recommended name Plectin Short names PCN; PLTN Alternative names Hemidesmosomal protein 1 ( HD1) Plectin-1 Gene names Name … WebbNeurofilament light polypeptide, also known as neurofilament light chain, abbreviated to NF-L or Nfl and with the HGNC name NEFL is a member of the intermediate filament protein family. This protein family consists of over 50 human proteins divided into 5 major classes, the Class I and II keratins, Class III vimentin, GFAP, desmin and the others, the …

Webb12 dec. 2005 · To monitor expression of plectin 1 on the protein level and to study its cellular localization, we raised isoform-specific antibodies. Rabbits were immunized with recombinant fusion proteins containing plectin 1-specific sequences, and antibodies highly specific for plectin 1 were obtained by affinity purification. Webb11 juli 2016 · RNA-binding proteins (RBPs) have essential roles in determining the fate of RNA from synthesis to decay and have been studied on a protein-by-protein basis, or computationally based on a number of ...

WebbObjectives To assess whether BP patients have autoantibodies targeting plectin, another hemidesmosomal component showing extensive homology to BP230. ... Conclusions Our results indicate that sera from BP patients might contain autoantibodies binding to plectin. Although this protein and BP230 are closely sequence-related, ... Webb8 jan. 2024 · The PLEC gene (PLEC is the acronym for plectin) is a protein-coding gene located on 8q24.3. Until 2010, this gene locus was named Plectin 1 (symbol PLEC1 in humans), and the gene product was referred to as "hemidesmosomal protein 1" or "Plectin 1, intermediate filament binding 500kDa". These designations have been replaced by …

Webb18 okt. 2024 · Plectin proteins encoded by isoforms 1a and 1f have been shown to be located on cancer cell surface 19. We examined the expression of different plectin …

WebbThe Pathology section contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analysis based on mRNA expression levels of human … recessive genetics def recessive pedigree worksheetWebbWe generated EBS-Ogna knock-in mice mimicking the human phenotype and show that blistering reflects insufficient protein levels of the hemidesmosome-associated plectin isoform 1a. We found that plectin 1a, in contrast to plectin 1c, the major isoform expressed in epidermal keratinocytes, is proteolytically degraded, supporting the notion that … unleash evgaWebb31 juli 2024 · Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene ( PLEC) cause several rare … recessive trait genotypeWebb13 jan. 2015 · PLEC:plectin [Gene - OMIM - HGNC] Variant type: single nucleotide variant Cytogenetic location: 8q24.3 Genomic location: Chr8: 143921326 (on Assembly GRCh38) Chr8: 144995494 (on Assembly GRCh37) ... Protein change: R2800H Links: dbSNP: rs6558407 NCBI 1000 Genomes Browser: rs6558407 unleash event las vegasWebb30 aug. 2024 · Moreover, plectin is a scaffolding protein known to bind to the receptor for activated C kinase 1 (RACK1), thus modulating protein kinase C (PKC) signaling … unleash faithWebb15 sep. 2013 · Plectin phosphorylated at S4642 was reduced at sites of IF network anchorage along cell-substrate contacts in both skin and cultured keratinocytes. Treatment of SK-MEL-2 and HeLa cells with okadaic acid increased plectin S4642 phosphorylation, suggesting that protein phosphatase 2A dephosphorylates this residue. recessiveness gene