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WebMay 26, 2024 · In CML, unusual changes to chromosomes cause bone marrow to produce too many of a type of white blood cell called granulocytes. Over time, immature white blood cells, called blasts, start to ... WebChronic myeloid leukemia (CML) occurs when a pluripotent stem cell undergoes malignant transformation and clonal myeloproliferation, leading to a striking overproduction of mature and immature granulocytes. Initially asymptomatic, CML progression is insidious, with a nonspecific “benign” stage (malaise, anorexia, weight loss) eventually ... el rancho pigeon forge tennessee
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