WebGroup 3 innate lymphoid cells (ILC3s), a novel subpopulation of lymphocytes enriched in the intestinal mucosa, are currently considered as key sentinels in maintaining intestinal immune homeostasis. ILC3s can secrete a series of cytokines such as IL-22 to eliminate intestinal luminal antigens, promote epithelial tissue repair and mucosal barrier integrity, … WebMar 1, 2024 · Cell death is a necessary event in multi-cellular organisms to maintain homeostasis by eliminating unrequired or damaged cells. Currently, there are many forms of cell death, and several of them, such as necroptosis, pyroptosis and ferroptosis, even apoptosis trigger an inflammatory response by releasing damage-associated molecular …
Mitochondria Related Cell Death Modalities and Disease
WebOct 13, 2024 · A new TRAIL of cell death. Signaling from TRAIL through its receptors (DR4/5) is well known to induce apoptosis (left path) by a mechanism involving formation of a death-induced signaling complex involving fas-associated death domain protein (FADD) and caspase-8, and subsequent activation of caspase-8 activity that leads to cell death. WebOct 28, 2024 · These phenomena can lead to cell death or, worse, to uncontrolled proliferation and cancer. Nitro-oxidative stress has thus been shown to be involved in a great number of pathologies, particularly those associated with low- or high-grade inflammation as well as cancer. The understanding of the biochemical mechanisms of its generation and … fix micr usb
Frontiers Editorial: Cell death: from its induction to the …
WebOct 31, 2024 · The exploration of the role of cell death in disease development as well as the modulation of cell death for treatment of diseases demands a constant update of our knowledge. This Special Issue highly welcomes original research articles, short communications, and review manuscripts. Interdisciplinary contributions will help to get a … WebApr 11, 2024 · Maintaining telomeres is vital for the health of a mammalian cell, as excessively shortened telomeres induce cell cycle arrest, senescence, and cell death. In actively proliferating cells, including cancers, two telomere maintenance mechanisms exist: (1) continued activation of telomerase; and (2) the alternative lengthening of telomeres … WebMar 4, 2024 · Over the past few years, the field of regulated cell death continues to expand and novel mechanisms that orchestrate multiple regulated cell death pathways are being unveiled. Meanwhile, … fix microwave smell